A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2542372
The present invention is directed to a method of using function blocking tissue factor antibodies to enhance graft survival in mammals. Function blocking antibodies having the effect of blocking activated tissue factor (TF), TF and its Logan FVII as either the inactive TF:FVII or active TF:FVIIa complex, or block the formation f the TF:FVIIa:FX ternary complex are useful in the method. These properties provide a therapy that has directed action towards thrombotic events involving tissue-plasma interactions but does not prevent the intrinsic pathway for coagulation. Activated TF arises on cells, tissues, and organs during or after transplantation and is a major cause of graft loss.
L'invention concerne un procédé d'utilisation d'anticorps anti-facteur tissulaire bloqueurs de fonction afin de stimuler la survie de greffon chez les mammifères. Les anticorps bloqueurs de fonction utilisés dans le procédé selon l'invention ont pour effet de bloquer le facteur tissulaire activé (TF), TF et son ligand FVII, soit sous la forme du complexe TF:FVII inactif, soit sous la forme du complexe TF:FVIIa actif, ou de bloquer la formation du complexe ternaire TF:FVIIa:FX. Ces propriétés produisent une thérapie qui dirige son action sur des événements thrombotiques impliquant des interactions tissu-plasma mais qui ne prévient pas la coagulation de la voie de passage intrinsèque. Le TF activé, qui surgit sur les cellules, les tissus et les organes pendant ou après la transplantation, est une cause majeure de perte de greffon.
Davis Janet
Jordan Robert
Kenyon Norma Sue
Tam Susan
Xu Gang
Centocor Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Miami
LandOfFree
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