Method of promoting myocyte proliferation and myocardial...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61P 9/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2364484

The present invention provides methods, pharmaceutical compositions, improved cell culture medium and kits for promoting myocyte proliferation and myocardial tissue repair following myocardial injury by contact with angiotensinogen, AI, AI analogues, AI fragments and analogues thereof, AII, AII analogues, AII fragments and analogues thereof and/or AII AT2 type 2 receptor agonists.

La présente invention concerne des méthodes, des compositions pharmaceutiques, des milieux de culture cellulaire améliorés et des trousses permettant de stimuler la prolifération de myocytes et la réparation des tissus myocardiques suite à une blessure myocardique par contact avec un angiotensinogène, une angiotensine I (AI), des analogues d'AI, des fragments d'AI et leurs analogues, une angiotensine II (AII), des analogues d'AII, des fragments d'AII et leurs analogues et/ou des agonistes de récepteur de type 2 d'AII AT¿2?.

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