Method of protecting against staphylococcal infection

Details Method of protecting against staphylococcal infection Method of protecting against staphylococcal infection

A - Human Necessities

61

K

A61K 39/085 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2603775

A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate the 336 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of Staphylococcus or various types of Staphylococcus aureus.

L'invention concerne une méthode de prévention ou de traitement d'une infection bactérienne à staphylocoque chez un individu. La méthode consiste à utiliser un vaccin associé renfermant l'antigène polysaccharide 336 pour protéger activement des individus exposés à des conditions susceptibles de favoriser le développement d'une infection bactérienne pouvant se produire dans le cadre d'un cathétérisme ou d'une intervention chirurgicale. Dans une variante, la méthode consiste à prélever des anticorps en réponse à l'antigène pour traiter ou pour assurer une protection passive aux individus. La méthode peut être utilisée sur une population de patients présentant un risque d'infection à différentes espèces de Staphylococcus aureus.

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