Method of providing disease-specific binding molecules and...

Details Method of providing disease-specific binding molecules and... Method of providing disease-specific binding molecules and...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2674140

Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.

L'invention porte sur de nouvelles molécules de liaison spécifiques, en particulier des anticorps humains ainsi que des fragments, des dérivés et des variantes de ceux-ci qui reconnaissent les néoépitopes de protéines associées à une maladie qui proviennent de protéines endogènes natives, mais qui sont prédominantes dans le corps d'un patient sous une forme de variante et/ou hors de leur contexte physiologique normal. L'invention propose, de plus, des compositions pharmaceutiques comportant de telles molécules de liaison, des anticorps et leurs mimétiques, et des procédés de criblage pour de nouvelles molécules de liaison, qui peuvent être ou ne pas être des anticorps, ainsi que des cibles dans le traitement de troubles neurologiques telles que la maladie d'Alzheimer.

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