Method of purifying .alpha.-l-aspartyl-l-phenylalanine...

Details Method of purifying .alpha.-l-aspartyl-l-phenylalanine... Method of purifying .alpha.-l-aspartyl-l-phenylalanine...

C - Chemistry, Metallurgy

07

K

C07K 5/075 (2006.01) C07K 1/14 (2006.01) C07K 5/072 (2006.01)

Patent

CA 2087325

Mixtures containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and 3-benzyl-6-carboxymethyl-2,5- dioxopiperazine, which are then separated from each other by classification. The method of the invention permits efficient purification of .alpha.-L-aspartyl-L-phenylalanine methyl ester.

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