Method of purifying daunomycin

Details Method of purifying daunomycin Method of purifying daunomycin

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01)

Patent

CA 2301654

The present invention relates to a method in which dauno-mycin is eluted from a hydrophobic porous synthetic resin carrier onto which daunomycin is adsorbed from crude daunomycin with a buffered aqueous solution containing a water-miscible organic solvent to recover purified daunomycin. Daunomycin (daunorubicin) is purified efficiently.

L'invention a pour objet un procédé qui consiste à adsorber la daunomycine provenant de la daunomycine crue sur un support en résine synthétique hydrophobe poreuse, à éluer la daunomycine avec une solution tampon aqueuse qui contient un solvant organique miscible à l'eau, puis à récupérer la daunomycine purifiée. Ce procédé permet une purification efficace de la daunomycine (daunorubicine).

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