Method of purifying lantibiotics

Details Method of purifying lantibiotics Method of purifying lantibiotics

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 14/315 (2006.01) C12N 9/48 (2006.01) C12N 9/50 (2006.01) C12N 9/66 (2006.01) C12N 9/68 (2006.01) C12N 9/70 (2006.01) C12N 9/72 (2006.01) C12N 9/74 (2006.01) C12N 9/76 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2501635

Disclosed is a method for purifying a lantibiotic from a crude or partially purified solution containing the lantibiotic. In preferred embodiments, the lantibiotic is nisin, although the common structural features of lantibiotics dictate the effectiveness of the disclosed purification methods for other members of the lantibiotic genus. The method includes the step of forming an incubation mixture comprising the solution containing the lantibiotic and a proteolytic enzyme, and incubating the mixture under conditions optimized for selective proteolytic activity.

L'invention concerne un procédé de purification d'un lantibiotique à partir d'une solution brute ou partiellement purifiée contenant le lantibiotique. Dans des modes de réalisation préférés, le lantibiotique est de la nisine, bien que les caractéristiques structurelles des lantibiotiques conditionnent l'efficacité des procédés de purification décrits des autres membres du genre lantibiotique. Ce procédé consiste à former un mélange d'incubation comprenant la solution qui contient le lantibiotique et une enzyme protéolytique, et à incuber le mélange des conditions optimisées en vue de l'activité protéolytique sélective.

Affiliated with

Also associated with

Rating

Method of purifying lantibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of purifying lantibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of purifying lantibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1892120