C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 67/58 (2006.01) C07C 67/60 (2006.01) C07C 67/62 (2006.01) C07C 69/33 (2006.01) C12P 7/62 (2006.01) C12P 7/64 (2006.01) C12P 17/06 (2006.01)
Patent
CA 2425883
A method of isolating or purifying plavastatin or its pharmacologically acceptable salt characterized by involving, in the process of isolating or purifying plavastatin or its pharmacologically acceptable salt, the step of extracting plavastatin by using an organic solvent represented by the formula CH3CO2R (wherein R represents alkyl having 3 or more carbon atoms) or the step of decomposing impurities by using an inorganic acid/an inorganic base; and compositions containing plavastatin sodium thus obtained.
L'invention concerne un procédé permettant d'isoler ou de purifier de la pravastatine ou le sel pharmaceutiquement acceptable de celle-ci. Le procédé consiste à extraire la pravastatine à l'aide d'un solvant organique représenté par la formule CH¿3?CO2R (dans laquelle R représente un alkyle comprenant au moins trois atomes de carbone), ou à décomposer les impuretés à l'aide d'une base inorganique et d'un acide inorganique. L'invention concerne également les compositions à teneur en sodium de pravastatine ainsi obtenues.
Hagisawa Minoru
Hamano Kiyoshi
Kojima Shunshi
Sugio Nobunari
Suzuki Mutsuo
Marks & Clerk
Sankyo Company Limited
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