Method of radio-labelling biomolecules

Details Method of radio-labelling biomolecules Method of radio-labelling biomolecules

A - Human Necessities

61

K

A61K 51/08 (2006.01) A61K 51/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2475522

A method of radio-labelling a biomolecule comprising contacting the biomolecule with a source of radionuclide, such as technetium, in the presence of a weak transfer ligand and optionally subsequently passing the mixture through a size-exclusion filtration process. Also claimed are kits comprising such novel compositions, especially lactoferrin coupled to chemotherapeutic agents, and uses therefor.

L'invention concerne un procédé de radio-marquage d'une biomolécule. Ce procédé consiste à placer cette biomolécule en contact avec une source de radionuclide, comme du technetium, en présence d'un ligand de transfert faible, et éventuellement, à soumettre ce mélange à un processus de filtration à exclusion en fonction de la taille. En outre, l'invention traite de kits comprenant ces nouvelles compositions, en particulier, la lactoferrine, couplée à des agents chimiothérapeutiques, et des utilisations de ces derniers.

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