Method of rational-based drug design using osteocalcin

Details Method of rational-based drug design using osteocalcin Method of rational-based drug design using osteocalcin

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01) A61K 45/00 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01) C30B 29/58 (2006.01) G01N 23/20 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2446527

The invention relates to a method of identifying a compound that affects osteocalcin activity, comprising obtaining a 3D structure of osteocalcin or a fragment thereof, designing a compound to interact with, or mimic, the 3D structure of osteocalcin or fragment thereof, obtaining the compound, and determining whether the compound affects osteocalcin activity.

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