Method of recovering shiga-like toxins and vaccines...

Details Method of recovering shiga-like toxins and vaccines... Method of recovering shiga-like toxins and vaccines...

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) A61K 39/108 (2006.01) C07K 1/22 (2006.01) C07K 14/25 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2288971

Disclosed are methods of purifying shiga-like toxins (SLTs) from Polymyxin B sulfate extracts of Verotoxin-producing Escherichia coli. The methods are facile, efficient and reproducible. In another aspect, the toxin is inactivated for use in a vaccine against SLT mediate disease conditions.

L'invention concerne des procédés de purification de toxines du type Shiga (SLT) à partir d'extraits de sulfate de polymyxine B d'Escherichi coli producteur de vérotoxine. Les procédés sont simples, efficaces et renouvelables. Selon une autre variante, la toxine est inactivée afin d'être utilisée dans un vaccin pour lutter contre les états pathologiques induits par SLT.

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