Method of reducing irritativeness of surface active agents...

A - Human Necessities – 61 – K

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A61K 9/10 (2006.01) A61K 9/00 (2006.01) A61L 12/08 (2006.01) C11D 1/94 (2006.01) C11D 3/00 (2006.01) C11D 3/386 (2006.01) C11D 1/74 (2006.01) C11D 1/90 (2006.01)

Patent

CA 2207170

A method to substantially eliminate irritativeness caused by surface active agents contained in an aqueous composition is provided. The method employs, in the production of said composition, in combination one or more surface active agents having an anionic active group with one or more nonionic surface active agents, with a mutual ratio of said one or more surface active agents having an anionic active group to said one or more nonionic surface active agents being 1:1 to 1:6 in concentration by weight. Aqueous compositions with reduced irritativeness as well as a method of solubilization of an insoluble or scarcely soluble pharmaceutical ingredient in producing an external-use aqueous pharmaceutical preparation are also provided.

L'invention porte sur une méthode qui permet une élimination substantielle de l'irritation causée par les agents tensioactifs contenus dans une composition aqueuse. La méthode fait appel, pour la production de ladite composition, à une combinaison d'un ou de plusieurs agents tensioactifs ayant un groupe anionique actif avec au moins un agent tensioactif non ionique, le rapport desdits agents tensioactifs ayant un groupe anionique actif et desdits agents tensioactifs non ioniques étant 1:1 à 1:6 en concentration massique. L'invention porte aussi sur des compositions aqueuses à action irritante réduite, de même qu'une méthode de solubilisation d'un ingrédient pharmaceutique insoluble ou à peine soluble pour produire une préparation pharmaceutique aqueuse à usage externe.

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