C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/07 (2006.01) A61K 38/17 (2006.01) C07K 5/113 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2576768
The invention provides methods and materials related to inhibiting the effects of A.beta. such as neuronal cell death and tau phosphorylation. For example, the invention provides polypeptides, compositions containing polypeptides, transgenic animals, and methods for preventing an A.beta. effect (e.g., neuronal cell death in a mammal).
L'invention concerne des méthodes et des matériaux permettant d'inhiber les effets de A.beta. tels que la mort des cellules neuronales et la phosphorylation tau. Par exemple, elle concerne des polypeptides, des compositions contenant des polypeptides, des animaux transgéniques et des méthodes servant à prévenir un effet A.beta., par exemple, la mort cellulaire neuronale ou apoptose neuronale chez un mammifère.
Johnson Jeffrey A.
Stein Thor D.
Goudreau Gage Dubuc
Wisconsin Alumni Research Foundation
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