Method of reducing the risk of adverse cardiovascular (cv)...

A - Human Necessities – 61 – K

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A61K 31/549 (2006.01) A61K 31/22 (2006.01) A61K 31/365 (2006.01) A61K 31/366 (2006.01) A61K 31/401 (2006.01) A61K 31/4152 (2006.01)

Patent

CA 2619386

Methods and compositions for reducing the risks of adverse cardiovascular (CV) events associated with the administration of pharmaceutical agents which induce or increase the risk of one or more adverse CV events, particularly the non-steroidal anti-inflammatory drags (NSAIDs) and especially the cyclooxygenase-2 (COX-2) inhibitors, are disclosed. The methods involve the administration of compositions comprising the adverse CV event-inducing agent and additional pharmaceutical agents for reducing the risk of adverse CV events. In specific embodiments, the agent is selected from the group consisting of hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins), angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs).

Méthodes et compositions permettant d'atténuer les risques d'épisodes cardio-vasculaires dommageables associés à l'administration d'agents pharmaceutiques induisant au augments les risques de survenue de tels épisodes, en particulier de médicaments anti-inflammatoires non stéroïdiens et singulièrement les inhibiteurs de la cyclooxygénase-2. Ces méthodes consistent à administrer les compositions renfermant l'agent induisant des épisodes cardio-vasculaires dommageables plus des agents pharmaceutiques qui atténuent les risques de survenue de tels épisodes. Dans des modes de réalisation spécifiques, l'agent est pris dans le groupe composé d'inhibiteurs d'hydroxyméthylglutaryl-coréductase A (statines), d'inhibiteurs de l'enzyme de conversion de l'angiotensine (ACE) et de bloqueurs du récepteur de l'angiostatine II (ARB).

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