Method of reducing tissue damage associated with non-cardiac...

Details Method of reducing tissue damage associated with non-cardiac... Method of reducing tissue damage associated with non-cardiac...

A - Human Necessities

61

K

A61K 31/405 (2006.01) A61K 31/00 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/427 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2223317

Disclosed is a use for preventing non-cardiac tissue damage resulting from ischemia and/or hypoxia, of a glycogen phosphorylase inhibitor in the form of a pharmaceutical composition containing the glycogen phosphorylase inhibitor. The glycogen phosphorylase inhibitor may be represented by the formula I or IA: (see fig. I) (see fig. II) (wherein the dotted line is an optional bond; A is CH=, CH2, or the like; R1, R10 and R11 are H, halo, nitro, alkyl or the like; R2 is H; R3 is H or alkyl; R4 is H, alkyl, hydroxyalkyl or the like; R5 is H or the like; R6 is carboxy or the like; R7 is H, alkyl or the like), and is for example, 5-chloro-1H- indole-2-carboxylic acid [(1S)-benzyl-2-(3-hydroxyazetidin-1- yl)-2-oxo-ethyl]amide.

Pour prévenir les lésions tissulaire non cardiaques, résultant d'ischémies et (ou) d'hypoxies, l'invention présente un inhibiteur de la glycogène phosphorylase sous la forme d'une composition pharmaceutique renfermant l'inhibiteur. Ce dernier peut être représenté par la formule I ou IA (voir fig. I) (voir fig. II) (où la ligne en pointillé est une liaison facultative; A est CH=, CH2 ou un groupe analogue; R1, R10 et R11 sont un hydrogène, un halogène, un nitro, un alkyle ou groupe analogue; R2 est H; R3 est H ou un alkyle; R4 est un H, un alkyle, un hydroxyalkyle ou un groupe analogue; R5 est un H ou un élément analogue; R6 est un carboxy ou un groupe analogue; R7 est un H, un alkyle ou un groupe analogue); par exemple, l'acide 5-chloro-1H- indole-2-carboxylique ¢(1S)-benzyl-2-(3-hydroxyazétidin-1-yl)-2-oxoéthyl!amide.

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