Method of refolding tissue factor pathway inhibitor

Details Method of refolding tissue factor pathway inhibitor Method of refolding tissue factor pathway inhibitor

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 31/198 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61K 47/18 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01) C07K 1/00 (2006.01) C07K 1/113 (2006.01) C07K 1/14 (2006.01) C07K 1/16 (2006.01) C07K 1/18 (2006.01) C07K 1/30 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2450795

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

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