Method of removing abnormal prion protein from blood products

Details Method of removing abnormal prion protein from blood products Method of removing abnormal prion protein from blood products

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2657514

[PROBLEMS] To provide a method of conveniently and efficiently removing an abnormal prion from a blood preparation. To provide a method whereby an abnormal prion and leucocytes can be simultaneously removed. [MEANS FOR SOLVING PROBLEMS] A method of removing an abnormal prion from a blood preparation characterized by comprising filtering the blood preparation through a filter packed with a support coated with a polymer, which is composed of three units including 20% by mol or more but not more than 40% by mol of a unit originating in a hydrophobic polymerizable monomer, 5% by mol or more but not more than 13% by mol of a unit originating in a polymerizable monomer having a basic nitrogen-containing moiety, and a unit originating in a polymerizable monomer having a protonic neutral hydrophilic moiety as the balance, and then recovering the filtered blood preparation.

L'invention a pour objet un procédé d'élimination de façon commode et efficace d'un prion anormal dans une préparation à base de sang ; et un procédé par lequel un prion anormal et les leucocytes peuvent être simultanément enlevés. L'invention concerne un procédé d'élimination d'un prion anormal dans une préparation à base de sang caractérisé en ce qu'il consiste à : filtrer la préparation à base de sang sur un filtre garni d'un support de filtration recouvert d'un polymère, lequel est composé de trois unités comprenant 20 % en moles ou plus mais pas plus de 40 % en moles d'une unité provenant d'un monomère polymérisable hydrophobe, 5 % en moles ou plus mais pas plus de 13 % en moles d'une unité provenant d'un monomère polymérisable ayant une entité contenant de l'azote basique et le reste etant composé d'une unité provenant d'un monomère polymérisable ayant une entité hydrophile neutre protonique ; et ensuite récupérer la préparation à base de sang filtrée.

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