Method of removing formyl groups from n-formyl-amino...

C - Chemistry – Metallurgy – 07 – K

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530/5.04, 260/48

C07K 5/075 (2006.01) C07K 1/12 (2006.01)

Patent

CA 1042875

ABSTRACT OF THE DISCLOSURE The masking N-formyl group of an N-formul-amino acid ester or N-formyl-peptide ester is removed without major side reactions when the ester is reacted in an inert liquid medium with hydroxylamine of which at least 70% is present in the form of a salt with a strong acid, the remainder, if any, being present as the free base or the salt of a weak acid.

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