Method of resolving amlodipine racemate

Details Method of resolving amlodipine racemate Method of resolving amlodipine racemate

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01)

Patent

CA 2466806

The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 greater than 0.75:1Ø

L'invention se rapporte à des procédés de dissolution d'amlodipine racémique en compositions énantiomériquement enrichies par précipitation avec un acide tartarique en présence d'un solvant non aqueux notamment un N,N'-diméthylacétamide. Le rapport molaire d'acide tartarique d'amlodipine est de préférence inférieur à 0,25:1,0 ou supérieur à 0,75:1,0.

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