A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 35/34 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2260808
The present invention relates to a method for improving the success of a transplantation which at least addresses to one of the most serious problems: transplant survival. The method comprises the steps of transplanting donor cells in a patient in need for such a transplantation, the transplantation being made in the presence of an agent blocking the interaction between a ICAM- 1 molecule located at the membrane surface of the donor cell and a LFA-1 molecule located at the membrane surface of the patient's leucocytes, which blocking increases the viability of said transplanted donor cells by at least about four fold. The agent blocking this interaction is an anti-LFA-1 antibody which is injected to the host at the time of transplantation or an anti-ICAM-1 antibody fragment which is not capable of fixing complement, such as a F(ab)2 fragment.
L'invention concerne une méthode pour améliorer les chances de réussite d'une transplantation. Cette invention vise à résoudre, en particulier, un des problèmes les plus sérieux rencontrés lors de transplantations, qui est celui de la survie du transplant. La méthode consiste à transplanter les cellules du donneur sur un patient nécessitant une telle transplantation, la transplantation étant faite en présence d'un agent bloquant l'interaction entre une molécule ICAM-1, se trouvant sur la surface de la membrane des cellules du donneur et la molécule LFA-1, située sur la surface des membranes des leucocytes du patient, ce blocage améliorant la viabilité desdites cellules transplantées du donneur par un facteur d'au moins quatre. L'agent bloquant cette interaction est un anticorps anti-LFA-1 qui est injecté à l'hôte au moment de la transplantation ou un fragment d'anticorps anti-ICAM-1 qui n'est pas capable de fixer le complément, par exemple le fragment F(ab)¿2?.
Guerette Benoit
Roy Raynald
Tremblay Jacques P.
Vilquin Jean-Thomas
Goudreau Gage Dubuc
Universite Laval
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