Method of screening antiobesity agents and animal model of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2518627

Angiopoietin-related growth factor (AGF) promoter; a vector containing the promoter; a transformant containing the promoter; and a method of screening an anti-obestic medicine, a diabetic medicine and/or a cholesterol-lowering agent, in which use is made of the transformant. Further, there is disclosed an AGF knockout animal useful as a model animal for obesity, diabetes and/or hyperlipemia. Still further, there is disclosed an AGF transgenic animal useful for identification of target molecule in new drug development and/or a therapeutic agent for obesity, diabetes and/or hyperlipemia.

La présente invention concerne un promoteur du facteur de croissance lié à l'angiopoïétine (AGN) ; un vecteur contenant ledit promoteur ; un transformant contenant le promoteur ; et un procédé de criblage d'un médicament contre l'obésité, d'un médicament contre le diabète et/ou d'un agent réducteur du taux de cholestérol dans lesquels le transformant précité est utilisé. L'invention se rapporte en outre à un animal à AGN inactivé (knock-out AGN) utilisé comme modèle animal de l'obésité, du diabète et/ou de l'hyperlipémie. L'invention se rapporte enfin à un animal à AGF transgénique utilisé pour l'identification d'une molécule cible dans la mise au point d'un nouveau médicament et/ou d'un agent thérapeutique contre l'obésité, le diabète et/ou l'hyperlipémie.

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