G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 24/08 (2006.01) G01R 33/46 (2006.01) G01R 33/465 (2006.01)
Patent
CA 2400867
The present invention provides a method of screening compounds to identify ligands that bind to specific target molecules using nuclear magnetic resonance (NMR) and the measurement of residual dipolar couplings. The method is particularly useful in screening and/or identifying compounds which bind to specific target molecules, for example proteins, polypeptides and macromolecules so as to assist in rational drug design.
La présente invention concerne une méthode de criblage de composés destinée à identifier les ligands se liant à des molécules cible spécifiques par l'utilisation de la résonance magnétique nucléaire (NMR), et la mesure des couplages dipolaires résiduels. Cette méthode est particulièrement utile dans le criblage et/ou l'identification de composés se liant à des molécules cible spécifiques, telles que des protéines, des polypeptides et des macromolécules, en vue de la conception rationnelle de médicaments.
Homans Steven William
Shimizu Hiroki
Ridout & Maybee Llp
University Of Leeds
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