Method of screening for compounds with anti-amyloid properties

Details Method of screening for compounds with anti-amyloid properties Method of screening for compounds with anti-amyloid properties

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2661122

The invention relates to a method of screening for compounds with anti-amyloid properties. The method of screening for compounds which have the ability to dissociate or prevent high-affinity complexes between .beta.-amyloid peptides and nicotinic acetylcholine receptors of human cortex tissues makes it possible to rapidly identify compounds for use in the curative and/or preventive treatment of neurodegenerative diseases and of Alzheimer's disease in particular.

L'invention concerne une méthode de criblage de composés aux propriétés anti-amyloïde. La méthode de criblage de composés ayant l'aptitude de dissocier ou prévenir des complexes de forte affinité entre les peptides .beta.-amyloïde et les récepteurs nicotiniques de L'acétylcholine de tissus de cortex humains permet d'identifier rapidement des composés destinés au traitement curatif et/ou préventif des maladies neurodégénératives et de la maladie d'Alzheimer en particulier.

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