Method of screening for genetic predisposition to...

Details Method of screening for genetic predisposition to... Method of screening for genetic predisposition to...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/46 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2209683

A method of screening for a genetic predisposition to anticholinesterase exposure. The method includes the steps of obtaining a peripheral blood sample, and then analysing serum from the blood sample for BuChE levels and inhibitor-susceptibilities. The DNA of peripheral white blood cells from the blood sample is also screened for the presence of BuChE alleles thereby identifying patients who have a genetic predisposition to anticholinesterase exposure.

L'invention se rapporte à un procédé de dépistage d'une prédisposition génétique à une exposition aux agents anticholinostérasiques. Ce procédé consiste à obtenir un échantillon de sang périphérique, puis à analyser le sérum de l'échantillon de sang pour obtenir des taux de BuChE et déterminer les niveaux de sensibilité aux inhibiteurs. L'ADN des globules blancs du sang périphérique de l'échantillon de sang est également passé au crible pour détecter la présence d'allèles de BuChE, ce qui permet d'identifier des patients présentant une prédisposition génétique à l'exposition aux agents anticholinestérasiques.

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