Method of selecting cells for somatic cell nuclear transfer

Details Method of selecting cells for somatic cell nuclear transfer Method of selecting cells for somatic cell nuclear transfer

A - Human Necessities

01

K

A01K 67/00 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2501415

The present invention provides for the production of homozygous primary cells that carry a specific transgenic integration if interest on both chromosomes by bypassing breeding. These cell lines can they be used for the accelerated production of homozygous transgenic animals by somatic cell nuclear transfer. The invention is thus useful in the production of transgenic ungulate animals capable of producing desired biopharmaceuticals in their milk at higher yield than a comparable heterzygote. By combining the selection techniques of the current invention with somatic cell nuclear transfer it can be applied to large animals, where there is a strong need to shorten the time to homozygosity.

L'invention concerne la production de cellules primaires homozygotes comportant une intégration transgénique spécifique d'intérêt sur les deux chromosomes par dérivation de la sélection. Ces lignes de cellules peuvent être utilisées en vue de produire de façon accélérée des animaux transgéniques homozygotes par transfert nucléaire de cellules somatiques. L'invention est donc utile dans la production d'animaux ongulés transgéniques capables de produire des produits biopharmaceutiques souhaités dans leur lait en quantité supérieure par rapport aux cellules hétérozygotes. Par combinaison des techniques de sélection de cette invention avec un transfert nucléaire de cellules somatiques, lesdites techniques peuvent être appliquées à des grands animaux, lorsqu'il y a un besoin important de raccourcir le temps de l'homozygotie.

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