Method of selecting non-pathogenic gram-positive lactic acid...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/04 (2006.01) A61K 35/74 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2450444

The invention relates to a method of selecting non-pathogenic Gram-positive lactic acid bacteria strains that can combat infections by pathogenic bacteria for which the pathogenicity is the result of a tissue adhesion. The inventive method consists in choosing a strain presenting all of the following properties: a) the ability to adhere to tissues of an organ that is likely to be infected; b) the ability of the bacteria of said strain to fix to one another via mutual adhesion sites; and c) the ability to fix to the attachment determinants of the pathogenic bacterial strain responsible for the infection. The bacterial strains thus selected can be used in the production of therapeutic compositions that are intended to prevent or treat pathological conditions associated with the infection of the host's organ by pathogenic bacterial strains.

La présente invention concerne un procédé de sélection de souches de bactéries lactiques à Gram positif non pathogènes capables de lutter contre des infections par des bactéries pathogènes pour lesquelles la pathogénicité est consécutive à une adhésion tissulaire, consistant à choisir une souche présentant l'ensemble des propriétés suivantes :a - la capacité d'adhérer aux tissus d'un organe susceptible d'être infecté ;b - la capacité des bactéries de cette même souche de se fixer les unes aux autres via des sites d'adhésion mutuelle ; et - la capacité de se fixer aux déterminants d'attachement de la souche bactérienne pathogène responsable de l'infection. Les souches bactériennes ainsi sélectionnées sont utilisables dans la fabrication de compositions thérapeutiques destinées à prévenir ou traiter les troubles pathologiques associés à l'infection de l'organe d'un hôte par des souches bactériennes pathogènes.

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