Method of selectively increasing yield and purity of certain...

Details Method of selectively increasing yield and purity of certain... Method of selectively increasing yield and purity of certain...

C - Chemistry, Metallurgy

07

K

167/114, 530/3.2

C07K 14/755 (2006.01) A61K 35/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1158977

METHOD OF SELECTIVELY INCREASING YIELD AND PURITY OF CERTAIN CRYOPRECIPITATE PROTEINS Abstract of the disclosure AHF and CIg yield and purity in cryoprecipitate concentrate are improved by suspending said cryoprecipitate concentrate in aqueous solution and then subjecting to a heat treatment step at a temperature of from about 45°C to about 56°C for a period of from about one minute to about sixty minutes to thereby selectively thermally precipitate the contaminating proteins without substantial loss of AHF or CIg activities and recovering the purified AHF or CIg from the precipitate of contaminating proteins.

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