Method of separating a peptide from a resin

Details Method of separating a peptide from a resin Method of separating a peptide from a resin

C - Chemistry, Metallurgy

07

K

C07K 1/14 (2006.01) C07K 1/04 (2006.01)

Patent

CA 2108170

In solid phase peptide synthesis, resin-bound peptide is treated with hydrogen fluoride so as to cleave the peptide from the resin and form a first mixture of peptide, hydrogen fluoride and resin. The resin is removed from the first mixture so as to pro- vide a resin-free second mixture including the polypeptide and the hydrogen fluoride. The polypeptide of the second mixture then is separated from the hydrogen fluoride.

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