Method of separating prions from biological materials

Details Method of separating prions from biological materials Method of separating prions from biological materials

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 1/30 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2392015

Disclosed is a method for separating prions from biological materials. The method includes adding a polyalkylene glycol, such as polyethylene glycol, to a solution of the biological material such that a precipitate containing the prion is formed. This precipitate is then separated from the solution of biological material, thereby removing prions. Biological materials include biologically derived fluids, such as cerebrospinal fluid, biological samples, such as brain homogenates, blood plasma fractions, and aqueous solutions of recombinantly produced products. The disclosed method provides an effective process for the removal of these infectious materials from the biological materials, which may be further processed to provide the therapeutic compositions.

L'invention porte sur un procédé de séparation de prions d'avec des matériaux biologiques consistant à ajouter à une solution d'un tel matériau un polyalkylène glycol tel qu'un polyéthylène glycol, pour former un précipité contenant les prions, qu'on peut ensuite séparer de la solution pour en extraire les prions. Lesdits matériaux biologiques comportent des fluides biologiques tels que le liquide céphalo-rachidien, ou des prélèvements biologiques tels que des homogénéisats cérébraux, des fragments de plasma sanguin, ou des solutions aqueuses de produits de recombinaison. Ledit procédé est un moyen efficace d'extraction de ces substances infectieuses des matériaux biologiques en vue de leur traitement ultérieur pour élaborer des compositions thérapeutiques.

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