Method of solubilizing proteins containing two...

Details Method of solubilizing proteins containing two... Method of solubilizing proteins containing two...

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 31/198 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) A61K 47/18 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01) C07K 1/00 (2006.01) C07K 1/113 (2006.01) C07K 1/14 (2006.01) C07K 1/16 (2006.01) C07K 1/18 (2006.01) C07K 1/30 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2450797

A method of modifying proton solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

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