Method of solubilizing, purifying, and refolding protein

Details Method of solubilizing, purifying, and refolding protein Method of solubilizing, purifying, and refolding protein

A - Human Necessities

61

K

A61K 38/55 (2006.01) A61K 31/198 (2006.01) A61K 38/57 (2006.01) A61K 47/18 (2006.01) A61K 47/30 (2006.01) A61K 47/36 (2006.01) C07K 1/00 (2006.01) C07K 1/113 (2006.01) C07K 1/14 (2006.01) C07K 1/16 (2006.01) C07K 1/18 (2006.01) C07K 1/30 (2006.01) C07K 14/81 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2450804

A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

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