Method of stabilizing antibody and stabilized solution-type...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/00 (2006.01) A61K 9/08 (2006.01) A61K 39/395 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2540848

It is intended to provide a method of inhibiting the formation of a soluble aggregate of an antibody in a solution; a method of inhibiting the formation of a chemically degraded product; and a method of stabilizing an antibody. It is also intended to provide a solution-type antibody preparation in which the formation of a soluble aggregate is inhibited; a solution-type antibody preparation in which the formation of a chemically degraded product is inhibited; a solution-type antibody preparation in which the formation of a soluble aggregate, the formation of a chemically degraded product and the formation of an insoluble aggregate are inhibited; an agent for inhibiting the formation of a soluble aggregate of an antibody; an agent for inhibiting the formation of a chemically degraded product of an antibody; and an antibody stabilizer.

L'objectif de l'invention est d'obtenir une méthode d'inhibition de la formation d'un agrégat soluble d'un anticorps dans une solution; une méthode d'inhibition de la formation d'un produit dégradé chimiquement; et une méthode de stabilisation d'un anticorps. L'objectif est également d'obtenir une préparation d'anticorps de type solution dans laquelle la formation d'un agrégat soluble est inhibée; une préparation d'anticorps de type solution dans laquelle la formation d'un produit dégradé chimiquement est inhibée; une préparation d'anticorps de type solution dans laquelle la formation d'un agrégat soluble, la formation d'un produit dégradé chimiquement et la formation d'un agrégat insoluble sont inhibées; un agent d'inhibition de la formation d'un agrégat soluble d'un anticorps; un agent d'inhibition de la formation d'un produit dégradé chimiquement d'un anticorps; et un stabilisant d'anticorps.

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