A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61P 9/10 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2535920
A method of stabilizing lipid-rich plaques and method of preventing the rupture thereof, characterized in that an effective amount of 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4 -bis(methylthio)-6-methyl-3-pyridyl]acetamide, its acid adduct salt or a hydrate thereof is administered to patients with lipid-rich plaques. Prevention of plaque rupture and stabilization of plaques can be attained by reducing the occupancy of macrophages in lipid-rich plaques being unstable and tending to rupture among plaques being a lesion from a seat of atherosclerosis and simultaneously increasing the occupancy of collagen therein.
L'invention concerne un procédé pour stabiliser des plaques riches en lipides et un procédé pour prévenir la rupture de ces plaques. Lesdits procédés se caractérisent en ce que du 2-[4-[2-(benzimidazol-2-ylthio)éthyl]pipérazin-1-yl]-N-[2,4-bis(méthylthio)-6-méthyl-3-pyridyl]acétamide, son sel d'addition acide ou un hydrate dudit composé sont administrés en quantité efficace à des patients ayant des plaques riches en lipides. On peut prévenir la rupture de plaques et stabiliser des plaques en réduisant la charge de macrophages dans des plaques riches en lipides instables et tendant à rompre parmi des plaques qui sont une lésion d'un siège d'athérosclérose puis en augmentant simultanément la charge de collagène.
Kobayashi Hideyuki
Shibuya Kimiyuki
Yoshinaka Yasunobu
Kowa Co. Ltd.
Ridout & Maybee Llp
LandOfFree
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