Method of stabilizing useful protein and useful protein...

A - Human Necessities – 61 – K

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A61K 38/21 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 47/08 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) C07K 1/02 (2006.01) C07K 14/555 (2006.01) C12N 1/21 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2267210

A method for stabilizing useful proteins characterized by mixing the useful proteins with aqueous solutions of compounds having a fundamental structure of arabic acid; and stabilized useful protein compositions wherein the useful proteins contain compounds having a fundamental structure of arabic acid. It is preferable to use acacia as the compounds having a fundamental structure of arabic acid, while the useful proteins are typified by cytokines. This method is particularly efficacious in stabilizing interferons. Also, processes for producing and stabilizing canine interferon-.gamma. are disclosed in detail.

La présente invention concerne un procédé permettant de stabiliser des protéines utiles. Ce procédé consiste à mélanger ces protéines utiles avec des solutions aqueuses de composés présentant la structure fondamentale de l'acide arabique. L'invention concerne également des compositions à base de telles protéines utiles stabilisées, lesquelles protéines utiles contiennent des composés présentant la structure fondamentale de l'acide arabique. Pour les composés présentant la structure fondamentale de l'acide arabique, on préfère le robinier rose. En outre, les protéines utiles sont typifiées par les cytokines. Ce procédé convient particulièrement à la stabilisation des interférons. L'invention concerne enfin plus particulièrement des procédés permettant de produire et stabiliser l'interféron-.gamma. d'origine canine.

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