A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/42 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2182800
The present invention relates to a method for stimulating hematopiesis in a mammal comprising administration of a therapeutically effective amount of a hemoglobin, including recombinant hemoglobin, and methods for treating cytopenias and cachexias associated with cytopenias. These cytopenias include anemia, thrombocytopenia, lymphopenia, neutropenia and the like. The stimulation of hematopoiesis can occur both in vivo and ex vivo, as in the treatment of cytopenias associated with disease states, in cell culture or ex vivo expansion of bone marrow cells.
L'invention concerne un procédé de stimulation de l'hématopoïèse chez un mammifère, consistant à administrer une dose thérapeutiquement efficace d'une hémoglobine, y compris une hémoglobine recombinée, ainsi que des procédés de traitement de cytopénies et de la cachexie associée à des cytopénies. On peut citer parmi ces cytopénies l'anémie, la thromocytopénie, la lymphopénie, la neutropénie et analogue. La stimulation de l'hématopoïèse peut avoir lieu à la fois in vivo et ex vivo, telle que dans le traitement de cytopénies associées à des états pathologiques, dans des bouillons de culture cellulaires ou bien dans le developpement ex vivo de cellules de la moelle osseuse.
Gerber Michael J.
Rosenthal Gary J.
Smart & Biggar
Somatogen Inc.
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