Method of stimulating the motility of the gastrointestinal...

Details Method of stimulating the motility of the gastrointestinal... Method of stimulating the motility of the gastrointestinal...

A - Human Necessities

61

K

A61K 38/06 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2709913

The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co- administering a ghrelin mimetic with a laxative, a H2 receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.

Cette invention concerne une méthode de stimulation de la motilité du système gastro-intestinal chez un sujet qui en a besoin, ledit sujet souffrant de maladies (troubles, affections, pathologie, ou dysfonctionnement après traitement pharmacologique ou intervention chirurgicale) du système gastro-intestinal, en administrant au sujet un mimétique de la ghréline, ou son sel pharmaceutiquement acceptable. L'invention concerne également une méthode de traitement d'une maladie gastro-intestinale en administrant conjointement un mimétique de la ghréline avec un laxatif, un antagoniste des récepteurs H2, un agoniste des récepteurs de la sérotonine, pur ou en mélange, un antiacide, un antagoniste des opioïdes, un inhibiteur de la pompe à protons, un agoniste des récepteurs de motiline, un antagoniste de la dopamine, un agoniste cholinergique, un inhibiteur de cholinestérase, la somatostatine, l'octréotide ou toute combinaison de ces composés.

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