Method of stimulating the motility of the gastrointestinal...

A - Human Necessities – 61 – K

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Details

A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61K 38/25 (2006.01)

Patent

CA 2576238

The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administering to a subject in need thereof a therapeutically effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be co-administered with a laxative, a H2 receptor antagonist, a serotonin 5-HT4 agonist, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.

La présente invention concerne une méthode de stimulation de la motilité du système gastro-intestinal chez un sujet souffrant de maladies (c'est-à-dire de troubles ou d'états pathologiques) du système gastro-intestinal. Ladite méthode consiste à administrer à un sujet en souffrance une quantité efficace d'un point de vue thérapeutique d'un composé sécrétagogue d'hormones de croissance ou d'un sel, hydrate ou solvate acceptable d'un point de vue pharmaceutique de celui-ci. Le sécrétagogue de l'hormone de croissance peut être co-administré avec un laxatif, un antagoniste du récepteur H2, un agoniste de la sérotonine 5-HT4, un anti-acide, un antagoniste des opioïdes, un inhibiteur de la pompe à protons, un agoniste du récepteur de la motiline, un antagoniste de la dopamine, un agoniste cholinergique, un inhibiteur de la cholinestérase, la somastatine, l'octréotide, ou une combinaison de ceux-ci.

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