Method of support-based chemical synthesis

Details Method of support-based chemical synthesis Method of support-based chemical synthesis

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07K 1/02 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2575745

A method of synthesis on a solid phase support is disclosed that provides a cleaved product containing a protecting group that would have been cleaved by reaction with anhydrous HF wherein the support is volatilized during cleavage of the protected product from the support by reaction with diluted HF.

L'invention concerne un procédé de synthèse sur support en phase solide, fournissant un produit clivé contenant un groupe de protection qui a été clivé par réaction avec HF anhydre, procédé caractérisé en ce que le support est volatilisé durant le clivage du produit protégé, à partir du support qui est mis à réagir avec HF dilué.

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