Method of synthesis and testing of combinatorial libraries...

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2520630

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

L'invention concerne une méthode destinée à la synthèse de composés. Ladite méthode consiste à (a) compartimenter au moins deux ensembles de composés primaires dans des microcapsules de telle manière qu'une proportion des microcapsules contient au moins deux composés et (b) former des composés secondaires dans les microcapsules par le biais de réactions chimiques entre des composés primaires provenant d'ensembles différents. Cette invention a aussi trait à l'identification de composés qui se lient à un composé cible d'un système biochimique ou modulent l'activité de la cible et qui sont co-compartimentés dans les microcapsules.

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