Method of synthesis of bosentan, its polymorphic forms and...

Details Method of synthesis of bosentan, its polymorphic forms and... Method of synthesis of bosentan, its polymorphic forms and...

C - Chemistry, Metallurgy

07

D

C07D 239/69 (2006.01) A61K 31/506 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2711043

The present invention relates to alkaline earth metal salts of bosentan, anhydrous bosentan, polymorphic forms thereof, amorphous bosentan and processes for preparing them. The present invention further relates to a process for the preparation of bosentan and its pharmaceutically acceptable salts.

La présente invention a pour objet des sels de métaux alcalino-terreux du bosentan, du bosentan anhydre, de leurs formes polymorphiques, du bosentan amorphe et des procédés pour leur préparation. La présente invention a également pour objet un procédé pour la préparation de bosentan et de sels de bosentan de qualité pharmaceutique.

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