Method of synthesizing camptothecin-relating compounds

Details Method of synthesizing camptothecin-relating compounds Method of synthesizing camptothecin-relating compounds

C - Chemistry, Metallurgy

07

D

C07D 491/147 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2683768

The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.

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