C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2741599
The present invention relates to methods for synthesizing macrolide compounds which are known to have antibacterial activity, and are useful in the therapy of bacterial infections in mammals. More specifically, the invention relates to methods for synthesizing the macrolide antibiotic, gamithromycin utilizing a novel configuration of catalysts, chemical structures, and/or methods. An embodiment of the present invention may include allowing multiple chemical reactions to proceed without the isolation of chemical intermediates. Thus, multiple reactions may occur in one reaction vessel allowing for a considerable decrease in the cycle-time. The present invention also provides a novel method for inhibiting degradation while isolating a structure of a pharmaceutical composition.
Cette invention concerne des méthodes de synthèse de composés macrolides, composés connus pour leur activité antibactérienne et utiles dans le traitement des infections bactériennes chez le mammifère. Linvention concerne plus particulièrement des méthodes de synthèse de la gamithromycine, antibiotique macrolide, utilisant une nouvelle configuration de catalyseurs, de structures chimiques et/ou de méthodes. Un mode de réalisation de linvention peut comprendre lexécution de plusieurs réactions chimiques sans isolement des intermédiaires chimiques. Plusieurs réactions peuvent ainsi se produire dans une seule cuve réactionnelle ce qui permet de réduire considérablement la durée du cycle de réaction. Linvention concerne par ailleurs un nouveau procédé permettant déviter de dégrader tout en isolant la structure dune composition pharmaceutique.
Heggie William
Henriques Antonio Carlos Silva
Mendes Zita
Merial Limited
Smart & Biggar
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