Method of synthesizing phosphorothioate oligonucleotides

Details Method of synthesizing phosphorothioate oligonucleotides Method of synthesizing phosphorothioate oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2276213

This disclosure presents a method for the synthesis of phosphorothioate oligonucleotides using support-bound phosphoramidite intermediates. Phosphoramidite intermediates useful in the execution of the method described are also disclosed.

L'invention concerne une méthode permettant de synthétiser des oligonucléotides phosphorothioatés au moyen d'intermédiaires à base de phosphoramidites fixés sur un support. Elle concerne également les intermédiaires à base de phosphoramidites utiles pour mettre en oeuvre ladite méthode.

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