Method of testing remedy or preventive for hyperlipemia

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) A61K 48/00 (2006.01) A61P 3/06 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/563 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2390676

A novel method of testing a remedy or a preventive for hyperlipemia; and a nucleic acid probe, a primer and an antibody which are employed in this method. More particularly speaking, a method of testing the effect of a test substance as a remedy or a preventive for hyperlipemia by using the expression of a gene represented by SEQ ID NO:1 or 2 in Sequence Listing, which participates in the control of the blood neutral fat level of mammalians, as an indication; and a nucleic acid probe, a primer and an antibody employed in this method. By using this method, candidates for preventives or remedies for hyperlipemia can be searched for.

L'invention concerne un nouveau procédé d'essai d'agent curatif ou préventif de l'hyperlipémie, ainsi qu'une sonde d'acide nucléique, une amorce et un anticorps utilisés dans ce procédé. Plus précisément, l'invention concerne un procédé destiné à tester l'effet d'une substance d'essai en tant qu'agent curatif ou préventif de l'hyperlipémie par utilisation, comme indication, de l'expression d'un gène représenté par SEQ ID NO:1 ou 2 dans la liste des séquences, qui participe à la régulation du taux de graisses neutres dans le sang chez les mammifères; ainsi qu'une sonde d'acide nucléique, une amorce et un anticorps utilisés dans ce procédé. Grâce à ce procédé, il est possible de rechercher des agents curatifs ou préventifs candidats de l'hyperlipémie.

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