Method of the diagnosis of renal disorder, hemolytic-uremic...

Details Method of the diagnosis of renal disorder, hemolytic-uremic... Method of the diagnosis of renal disorder, hemolytic-uremic...

G - Physics

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G01N 33/53 (2006.01) C12Q 1/10 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2386895

Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease at an early stage, and for diagnosing the severity of these diseases are provided. Detection of excretion of AQP2 and/or molecules derived therefrom into urine of a subject, or determination of the amount of excretion of the same is conducted to diagnose the morbidity or the severity of renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease of the subject. For the detection and determination of AQP2, an immunochemical process may be suitably employed in which an antibody that specifically recognizes AQP2.

La présente invention concerne un procédé de diagnostic précoce de trouble rénal, du syndrome hémolytique et urémique et d'infection intestinale hémorragique colibacillaire à un stade précoce et un procédé de détermination de la gravité desdites affections. Le procédé de diagnostic de trouble rénal, du syndrome hémolytique et urémique et d'infection intestinale hémorragique colibacillaire et de détermination de la gravité desdites affections met en oeuvre une détection ou une quantification de AQP2 et/ou des molécules qui en sont dérivées présentes dans l'urine d'un sujet par excrétion. L'invention propose un procédé immuno-chimique par l'utilisation d'un anticorps de reconnaissance spécifique de l'APQ2 pour ladite détection ou quantification.

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