Method of therapeutic administration of dhe to enable rapid...

Details Method of therapeutic administration of dhe to enable rapid... Method of therapeutic administration of dhe to enable rapid...

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/48 (2006.01) A61P 25/06 (2006.01)

Patent

CA 2677838

Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

La présente invention concerne des compositions pharmaceutiques contenant de la dihydroergotamine (DHE) et des procédés dans lesquels la DHE est administrée à des patients pour le traitement de la migraine sans effets secondaires ou effets indésirables. Cette invention a également pour objet des procédés de traitement rapide de la migraine avec de la DHE comprenant : un amortissement du pic de concentration plasmatique (Cmax) et un léger retard du pic afin d'éviter l'activation des récepteurs dopaminergiques et adrénergiques, tout en obtenant une liaison active suffisante aux récepteurs de la sérotonine pour procurer un soulagement des symptômes de la migraine au sein d'un intervalle de temps qui permet une résolution rapide des symptômes de la migraine. Cette invention concerne des dispositifs d'inhalateurs appropriés pour les procédés et des kits pour pratiquer les procédés de l'invention.

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