C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01)
Patent
CA 2503317
It is intended to provide a method of transferring a gene into T cells which comprises the step of contacting a paramyxovirus vector with activated T cells. It is also intended to provide a method of producing T cells having a foreign gene transferred thereinto which comprises the step of contacting a paramyxovirus vector with activated T cells. Moreover, it is intended to provide T cells having a foreign gene transferred thereinto which are produced by the above method. Thus, a gene can be efficiently delivered specifically into activated T cells, which is expected as applicable to immunological modification strategies through T cell-directed gene delivery.
La présente invention concerne un procédé qui permet de transférer un gène dans des lymphocytes T, selon lequel on met un vecteur paramyxovirus en contact avec des lymphocytes T activés. L'invention se rapporte également à un procédé qui permet de produire des lymphocytes T dans lesquels un gène étranger a été transféré, selon lequel on met un vecteur paramyxovirus en contact avec des lymphocytes T activés. L'invention concerne en outre des lymphocytes T dans lesquels un gène étranger a été transféré, produits selon le procédé précité. L'invention permet de délivrer de façon efficace et spécifique un gène dans des lymphocytes T activés, et peut trouver une application dans des stratégies de modification immunologique via la délivrance de gènes dirigée sur les lymphocytes T.
Hasegawa Mamoru
Okano Shinji
Sueishi Katsuo
Yonemitsu Yoshikazu
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dnavec Research Inc.
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