Method of transmitting a biologically active material to a cell

Details Method of transmitting a biologically active material to a cell Method of transmitting a biologically active material to a cell

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2177695

A method for transmitting a biolog- ically active material to a cell is provided. The method involves encapsulating the ma- terial to be transmitted in a pancilamel- lar non-phospholipid carrier vesicle which does not lyse cells upon fusion with cells, delivering the carrier vesicle to a location proximate to the cell, allowing the non- phospholipid bilayer of the carrier vesicle to fuse with the membrane of the cell and al- lowing the encapsulated material to diffuse into the cell. The method can be used to transmit a variety of biologically active ma- terials to cells either in vivo or in vivo. The method provides a means for transmitting a biologically active material directly to the cytoplasm of a cell. Upon fusion with a cell, material associated with the bilayers of the non-phospholipid vesicle becomes in- corporated into the outer membrane of the cell. Accordingly, a method for transmit- ting bilayer-associated material to a cell is also provided.

Procédé pour la transmission à une cellule d'une substance à activité biologique. Ce procédé consiste à encapsuler la substance à transmettre dans une vésicule de transport non phospholipidique possédant un petit nombre de lamelles, qui ne lyse pas les cellules lors de sa fusion avec elles, à apporter la vésicule de transport en un site proche de la cellule, à laisser la double couche non phospholipidique de la vésicule de transport se fusionner avec la membrane de la cellule et à laisser la substance encapsulée se diffuser dans la cellule. Ce procédé peut être utilisé pour transmettre diverses substances ayant une activité biologique à des cellules, que ce soit in vitro ou in vivo. Il constitue un moyen de transmettre directement une substance à activité biologique au cytoplasme d'une cellule. Lors de la fusion avec une cellule, la substance associée à la double couche de la vésicule non phospholipidique est incorporée à la membrane extérieure de la cellule. En conséquence, un procédé de transmission à une cellule d'une substance associée à la double couche est également décrit.

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