Method of treating a condition associated with...

Details Method of treating a condition associated with... Method of treating a condition associated with...

A - Human Necessities

61

K

A61K 31/277 (2006.01) A61K 31/01 (2006.01) A61K 31/13 (2006.01) A61K 31/196 (2006.01) A61K 31/216 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/428 (2006.01) A61K 31/557 (2006.01) A61K 31/7076 (2006.01) A61K 33/00 (2006.01) A61K 38/45 (2006.01) A61K 45/00 (2006.01) A61P 9/06 (2006.01) A61P 13/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2617057

This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-1 agonist.

Cette invention concerne des méthodes et des compostions destinées au traitement d'états pathologiques associés à une phosphorylation du canal TASK-1 chez un sujet. Le traitement consiste à administrer une dose agent capable de surmonter une perte dépendant de la phosphorylation de la fonction TASK-1. Dans un mode de réalisation spécifique de l'invention, cet agent est un agoniste du canal TREK-1

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