A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/24 (2006.01) A61K 31/337 (2006.01) A61K 31/53 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2281807
In accordance with the present invention there is provided a method of treating a mammal having a solid tumor, the method comprising: a) administering to the mammal an effective amount of 3-amino- 1,2,4-benzotriazine 1.4-dioxide; b) administering to the mammal an effective amount of paclitaxel; and c) administering to the mammal an effective amount of a platinum complex. The method provides unexpected synergistic efficacy. The invention further provides a kit for treatment of a mammalian tumor comprising 3-amino-1,2,4-benzotriazine 1.4-dioxide, paclitaxel and a platinum complex.
La présente invention porte sur un traitement à appliquer à un mamifère atteint d'une tumeur solide, consistant à administrer au mamifère a) une quantité efficace de 3-amino-1,2,4-benzotriazine 1,4-dioxide, b) une quantité efficace de paclitaxel et c) une quantité efficace d'un complexe du platine. La méthode proposée a démontré une efficacité synergétique insoupçonnée. L'invention porte également sur une trousse conçue pour le traitement d'une tumeur de mamifère, comprenant ce qui suit: 3-amino-1,2,4-benzotriazine 1,4-dioxide, du paclitaxel et un complexe de platine.
Dexter Daniel L.
Juniewicz Paul E.
Rake James B.
von Hoff Daniel D.
Fetherstonhaugh & Co.
Sanofi Pharmaceuticals Inc.
Sri International
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